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Open Access Article

Journal of Modern Biotechnology Research. 2023; 1: (1) ; 26-33 ; DOI: 10.12208/j.jmbr.20230005.

Application and research progress of music in drug delivery
音乐在药物递送中的应用及研究进展

作者: 王瑞1, 桑慧芳2, 王裕霖3, 汪高原2, 汪小又1 *

1 西南大学药学院 重庆

2 西南大学音乐学院 重庆

3 新加坡国立大学杨秀桃音乐学院 新加坡

*通讯作者: 汪小又,单位: 西南大学药学院 重庆;

发布时间: 2023-09-14 总浏览量: 887

摘要

目前,声音对人体生理功能的影响及其机制越来越受到关注,音乐在辅助治疗方面也已有了一定应用基础。而在相关治疗中,往往还会涉及药物干预;同时,因其他原因使用药物的人群也不可避免地暴露在各种声音环境中。基于声音对人体内分泌与免疫,以及血流特性、吸收屏障等生理功能的影响,其对药物在体内的吸收、分布、代谢等情况以及最终的药物疗效有潜在的作用。然而,当前声音或音乐与药物递送相关的讨论仍相对较少,对于其中可利用的机制和可能的风险,均缺少关注。基于此,本文试针对音乐对药物递送的影响及相关研究进展进行浅述。

关键词: 声音;音乐;药物递送

Abstract

Currently, growing attention has been paid on the influence of sound on human physiological functions and the related mechanisms, and music therapies have also seen applications in many situations. Drug intervention, however, is often involved in these related treatments; meanwhile, people receiving medication are inevitably exposed to various kinds of sounds in their daily lives. Based on the impact of sound on human endocrine and immune systems, as well as physiological functions including blood flow characteristics and absorption barrier functions, sound has a potential role in the absorption, distribution, metabolism of drug and its final therapeutic outcome. However, the discussion of sound or music in relation to drug delivery is still lacking, especially the potential mechanisms to be utilized and possible risks involved. In this paper, the influence of music on drug delivery and related research progress will be briefly discussed.

Key words: Sound; Music; Drug delivery

参考文献 References

[1] Erkkilä J, Punkanen M, Fachner J, et al. Individual music therapy for depression: randomised controlled trial[J]. The British Journal of Psychiatry, 2011, 199(2):132–139.

[2] Geretsegger M, Fusar-Poli L, Elefant C, et al. Music therapy for autistic people[J]. Cochrane Database of Systematic Reviews, 2022(5).

[3] McDermott O, Crellin N, Ridder H M, et al. Music therapy in dementia: a narrative synthesis systematic review[J]. International Journal of Geriatric Psychiatry, 2013, 28(8):781–794.

[4] Partesotti E, Peñalba A, Manzolli J. Digital instruments and their uses in music therapy[J]. Nordic Journal of Music Therapy, 2018, 27(5):399–418.

[5] Hole J, Hirsch M, Ball E, et al. Music as an aid for postoperative recovery in adults: a systematic review and meta-analysis[J]. The Lancet, 2015, 386(10004): 1659–1671.

[6] Zhou W, Ye C, Wang H, et al. Sound induces analgesia through corticothalamic circuits[J]. Science, 2022, 377(6602): 198–204.

[7] Ascone L, Kling C, Wieczorek J, et al. A longitudinal, randomized experimental pilot study to investigate the effects of airborne infrasound on human mental health, cognition, and brain structure[J]. Scientific Reports, 2021, 11(1):3190.

[8] Vahl J M, Witzleben A von, Reiter R, et al. Infrasound a new weapon in cancer therapy?[J]. EXPLORE, 2022, 18(3):366–370.

[9] Liu N, Mishra K, Stiel A C, et al. The sound of drug delivery: Optoacoustic imaging in pharmacology[J]. Advanced Drug Delivery Reviews, 2022, 189:114506.

[10] Mitragotri S. Healing sound: the use of ultrasound in drug delivery and other therapeutic applications[J]. Nature Reviews Drug Discovery, 2005, 4(3):255–260.

[11] Lipsman N, Meng Y, Bethune A J, et al. Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound[J]. Nature Communications, 2018, 9(1):2336.

[12] Aryal M, Arvanitis C D, Alexander P M, et al. Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system[J]. Advanced Drug Delivery Reviews, 2014, 72:94–109.

[13] Tsai H-C, Tsai C-H, Chen W-S, et al. Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening[J]. Scientific Reports, 2018, 8(1):17720.

[14] Goutal S, Novell A, Leterrier S, et al. Imaging the impact of blood-brain barrier disruption induced by focused ultrasound on P-glycoprotein function[J]. Journal of Controlled Release, 2023, 361:483–492.

[15] Schoellhammer C M, Schroeder A, Maa R, et al. Ultrasound-mediated gastrointestinal drug delivery[J]. Science Translational Medicine, 2015, 7(310): 310 ra168-310 ra168.

[16] Schoellhammer C M, Chen Y, Cleveland C, et al. Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery[J]. Journal of Controlled Release, 2017, 268:113–119.

[17] Azagury A, Khoury L, Enden G, et al. Ultrasound mediated transdermal drug delivery[J]. Advanced Drug Delivery Reviews, 2014, 72:127–143.

[18] Manikkath J, Hegde A R, Kalthur G, et al. Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen[J]. International Journal of Pharmaceutics, 2017, 521(1):110–119.

[19] Ho Y-J, Li J-P, Fan C-H, et al. Ultrasound in tumor immunotherapy: Current status and future developments[J]. Journal of Controlled Release, 2020, 323:12–23.

[20] Shin S H, Park E-J, Min C, et al. Tracking Perfluorocarbon Nanoemulsion Delivery by 19F MRI for Precise High Intensity Focused Ultrasound Tumor Ablation[J]. Theranostics, 2017, 7(3):562–572.

[21] Sun T, Zhang Y, Power C, et al. Closed-loop control of targeted ultrasound drug delivery across the blood–brain/ tumor barriers in a rat glioma model[J]. Proceedings of the National Academy of Sciences, 2017, 114(48): E10281-E10290.

[22] Meng Z, Zhang Y, She J, et al. Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy[J]. Nano Letters, 2021, 21(3):1228–1237.

[23] Schwartz M R, Debski A C, Price R J. Ultrasound-targeted nucleic acid delivery for solid tumor therapy[J]. Journal of Controlled Release, 2021, 339:531–546.

[24] Zhang N, Wang J, Foiret J, et al. Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment[J]. Advanced Drug Delivery Reviews, 2021, 178:113906.

[25] Chen M, Liang X, Gao C, et al. Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer[J]. ACS Nano, 2018, 12(7):7312–7326.

[26] Batchelor D V B, Abou-Saleh R H, Coletta P L, et al. Nested Nanobubbles for Ultrasound-Triggered Drug Release[J]. ACS Applied Materials & Interfaces, 2020, 12(26):29085–29093.

[27] Xu Y, Liang X, Bhattarai P, et al. Enhancing Therapeutic Efficacy of Combined Cancer Phototherapy by Ultrasound-Mediated In Situ Conversion of Near-Infrared Cyanine/Porphyrin Microbubbles into Nanoparticles[J]. Advanced Functional Materials, 2017, 27(48):1704096.

[28] Santos M A, Wu S-K, Regenold M, et al. Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs[J]. Science Advances, 2020, 6(36):eaba5684.

[29] Huo S, Zhao P, Shi Z, et al. Mechanochemical bond scission for the activation of drugs[J]. Nature Chemistry, 2021, 13(2):131–139.

[30] Zhou Y, Huo S, Loznik M, et al. Controlling Optical and Catalytic Activity of Genetically Engineered Proteins by Ultrasound[J]. Angewandte Chemie International Edition, 2021, 60(3):1493–1497.

[31] Tu L, Liao Z, Luo Z, et al. Ultrasound-controlled drug release and drug activation for cancer therapy[J]. Exploration, 2021, 1(3):20210023.

[32] Canavese G, Ancona A, Racca L, et al. Nanoparticle- assisted ultrasound: A special focus on sonodynamic therapy against cancer[J]. Chemical Engineering Journal, 2018, 340:155–172.

[33] Gong Z, Dai Z. Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers[J]. Advanced Science, 2021, 8(10):2002178.

[34] Pu Y, Yin H, Dong C, et al. Sono-Controllable and ROS-Sensitive CRISPR-Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy[J]. Advanced Materials, 2021, 33(45):2104641.

[35] Moore C, Chen F, Wang J, et al. Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging[J]. Advanced Drug Delivery Reviews, 2019, 144:78–89.

[36] Moore C, Jokerst J V. Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging[J]. Theranostics, 2019, 9(6):1550–1571.

[37] Nilsson U, Unosson M, Rawal N. Stress reduction and analgesia in patients exposed to calming music postoperatively: a randomized controlled trial[J]. European Journal of Anaesthesiology | EJA, 2005, 22(2).

[38] Leardi S, Pietroletti R, Angeloni G, et al. Randomized clinical trial examining the effect of music therapy in stress response to day surgery[J]. British Journal of Surgery, 2007, 94(8):943–947.

[39] Eliakim M, Meckel Y, Nemet D, et al. The Effect of Music during Warm-Up on Consecutive Anaerobic Performance in Elite Adolescent Volleyball Players[J]. Int J Sports Med, 2007, 28(04):321–325.

[40] Hou Y-C, Lin Y-J, Lu K-C, et al. Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis[J]. Therapeutics and clinical risk management, 2017, 13:263–272.

[41] Chanda M L, Levitin D J. The neurochemistry of music[J]. Trends in Cognitive Sciences, 2013, 17(4):179–193.

[42] Conrad C, Niess H, Jauch K-W, et al. Overture for growth hormone: Requiem for interleukin-6?*[J]. Critical Care Medicine, 2007, 35(12).

[43] Okada K, Kurita A, Takase B, et al. Effects of Music Therapy on Autonomic Nervous System Activity, Incidence of Heart Failure Events, and Plasma Cytokine and Catecholamine Levels in Elderly Patients With Cerebrovascular Disease and Dementia[J]. International Heart Journal, 2009, 50(1):95–110.

[44] Fancourt D, Ockelford A, Belai A. The psychoneuroimmunological effects of music: A systematic review and a new model[J]. Brain, Behavior, and Immunity, 2014, 36:15–26.

[45] Rollenske T, Burkhalter S, Muerner L, et al. Parallelism of intestinal secretory IgA shapes functional microbial fitness[J]. Nature, 2021, 598(7882):657–661.

[46] Perruzza L, Strati F, Raneri M, et al. Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis[J]. Cell Reports, 2022, 40(3):111112.

[47] Núñez M J, Mañá P, Liñares D, et al. Music, immunity and cancer[J]. Life Sciences, 2002, 71(9):1047–1057.

[48] Sun Q, Zhou Z, Qiu N, et al. Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization[J]. Advanced Materials, 2017, 29(14): 1606628.

[49] Li J, Sharkey C C, Huang D, et al. Nanobiotechnology for the Therapeutic Targeting of Cancer Cells in Blood[J]. Cellular and Molecular Bioengineering, 2015, 8(1): 137–150.

[50] Müller K, Fedosov D A, Gompper G. Margination of micro- and nano-particles in blood flow and its effect on drug delivery[J]. Scientific Reports, 2014, 4(1):4871.

[51] Charoenphol P, Onyskiw P J, Carrasco-Teja M, et al. Particle-cell dynamics in human blood flow: Implications for vascular-targeted drug delivery[J]. Journal of Biomechanics, 2012, 45(16):2822–2828.

[52] Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery[J]. Nature Biotechnology, 2015, 33(9):941–951.

[53] Matsumoto Y, Nichols J W, Toh K, et al. Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery[J]. Nature Nanotechnology, 2016, 11(6):533–538.

[54] Banks W A. From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery[J]. Nature Reviews Drug Discovery, 2016, 15(4):275–292.

[55] Zhang B, Jiang T, Tuo Y, et al. Captopril improves tumor nanomedicine delivery by increasing tumor blood perfusion and enlarging endothelial gaps in tumor blood vessels[J]. Cancer Letters, 2017, 410:12–19.

[56] L Bernardi, C Porta, P Sleight. Cardiovascular, cerebrovascular, and respiratory changes induced by different types of music in musicians and non-musicians: the importance of silence[J]. Heart, 2006, 92(4):445.

[57] Mir I A, Chowdhury M, Islam R M, et al. Relaxing music reduces blood pressure and heart rate among pre-hypertensive young adults: A randomized control trial[J]. Journal of clinical hypertension (Greenwich, Conn.), 2021, 23(2):317–322.

[58] DA Silva, Sheila AP F, Guida H L, et al. Acute auditory stimulation with different styles of music influences cardiac autonomic regulation in men[J]. International cardiovascular research journal, 2014, 8(3):105–110.

[59] Evers S, Dannert J, Rödding D, et al. The cerebral haemodynamics of music perception. A transcranial Doppler sonography study[J]. Brain : a journal of neurology, 1999, 122 (Pt 1):75–85.

[60] Meyer G F, Spray A, Fairlie J E, et al. Inferring common cognitive mechanisms from brain blood-flow lateralization data: a new methodology for fTCD analysis[J]. Frontiers in psychology, 2014, 5:552.

[61] Semyachkina-Glushkovskaya O, Esmat A, Bragin D, et al. Phenomenon of music-induced opening of the blood-brain barrier in healthy mice[J]. Proceedings of the Royal Society B: Biological Sciences, 2020, 287(1941): 20202337.

[62] Semyachkina-Glushkovskaya O, Diduk S, Anna E, et al. Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain[J]. Frontiers in oncology, 2022, 12:1010188.

[63] Hatton G B, Madla C M, Rabbie S C, et al. Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption[J]. Drug Discovery Today, 2019, 24(2):417–427.

[64] Lin H-H, Chang W-K, Chu H-C, et al. Effects of music on gastric myoelectrical activity in healthy humans[J]. International journal of clinical practice, 2007, 61(7): 1126–1130.

[65] Chen D D, Xu X, Zhao Q, et al. Effects of audio stimulation on gastric myoelectrical activity and sympathovagal balance in healthy adolescents and adults[J]. Journal of gastroenterology and hepatology, 2008, 23(1):141–149.

[66] Bernardi L, Porta C, Sleight P. Cardiovascular, cerebrovascular, and respiratory changes induced by different types of music in musicians and non-musicians: the importance of silence[J]. Heart, 2006, 92(4):445–452.

[67] Sharkey K A, Beck P L, McKay D M. Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium[J]. Nature Reviews Gastroenterology & Hepatology, 2018, 15(12):765–784.

[68] Niu J, Xu H, Zeng G, et al. Music-based interventions in the feeding environment on the gut microbiota of mice[J]. Scientific Reports, 2023, 13(1):6313.

[69] Zhang X, Han Y, Huang W, et al. The influence of the gut microbiota on the bioavailability of oral drugs[J]. Acta Pharmaceutica Sinica B, 2021, 11(7):1789–1812.

[70] Namdar H, Taban Sadeghi M, Sabourimoghaddam H, et al. Effects of music on cardiovascular responses in men with essential hypertension compared with healthy men based on introversion and extraversion[J]. Journal of cardiovascular and thoracic research, 2014, 6(3):185–189.

[71] Wright S E, Palmer C. Physiological and Behavioral Factors in Musicians' Performance Tempo[J]. Frontiers in human neuroscience, 2020, 14:311.

[72] Vuust P, Heggli O A, Friston K J, et al. Music in the brain[J]. Nature Reviews Neuroscience, 2022, 23(5):287–305.

[73] Juslin P N, Västfjäll D. Emotional responses to music: The need to consider underlying mechanisms[J]. Behavioral and Brain Sciences, 2008, 31(5):559–575.

[74] Agres K R, Foubert K, Sridhar S. Music Therapy During COVID-19: Changes to the Practice, Use of Technology, and What to Carry Forward in the Future[J]. Frontiers in psychology, 2021, 12:647790.

[75] Witte M de, Spruit A, van Hooren S, et al. Effects of music interventions on stress-related outcomes: a systematic review and two meta-analyses[J]. Health Psychology Review, 2020, 14(2):294–324.

引用本文

王瑞, 桑慧芳, 王裕霖, 汪高原, 汪小又, 音乐在药物递送中的应用及研究进展[J]. 现代生物技术研究, 2023; 1: (1) : 26-33.