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Open Access Article

Journal of Modern Biotechnology Research. 2024; 2: (1) ; 1-6 ; DOI: 10.12208/j.jmbr.20240001.

Research advances in animal models of hyperbilirubinemia
高胆红素血症动物模型构建的研究进展

作者: 杨汐静1 *, 刘道龙2, 王洋3, 杨阳1

1四川大学华西医院动物实验中心 四川成都

2黑龙江珍宝岛药业股份有限公司 黑龙江哈尔滨

3新希望六和股份有限公司 四川成都

*通讯作者: 杨汐静,单位:四川大学华西医院动物实验中心 四川成都;

发布时间: 2024-01-12 总浏览量: 897

摘要

目前已经有很多种方法和动物种类可以构建高胆红素血症模型,如通过腹腔注射或者静脉注射胆红素、利用基因基因编辑技术构建基因缺陷动物模型、利用化学药物注射诱导、利用延髓直接注射胆红素的方法等。为了更深层探究高胆红素血症的发病机制以及改善和优化其治疗方法,本文收集并总结了高胆红素血症各类动物模型的构建方法以及优缺点,为高胆红素血症模型的建立提供了参考,对后续临床研究高胆红素症机制及治疗具有重要意义。

关键词: 高胆红素血症;动物实验;疾病模型;胆红素;新生儿

Abstract

There are many methods and animal species to establish animal models of hyPerbilirubinemia, such as abdominal or intravenous injection of bilirubin, the use of gene defective animal models, the use of chemical injection induction, and the direct injection of bilirubin into the medulla oblongata and so on. In order to further explore the pathogenesis of hyperbilirubinemia and improve and optimize its treatment methods, This paper collected and summarized the construction methods, advantages and disadvantages of various animal models of hyperbilirubinemia, providing a reference for the establishment of hyperbilirubinemia models, which is of great significance for subsequent clinical research on the mechanism and treatment of hyperbilirubinemia.

Key words: Hyperbilirubinemia; Animal experiment; disease model; bilirubin; Neonatal

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引用本文

杨汐静, 刘道龙, 王洋, 杨阳, 高胆红素血症动物模型构建的研究进展[J]. 现代生物技术研究, 2024; 2: (1) : 1-6.