期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

Journal of Modern Biotechnology Research. 2024; 2: (1) ; 43-47 ; DOI: 10.12208/j.jmbr.20240008.

Research progress of biotechnology in medicine
生物技术在医学中的研究进展

作者: 苏玉斌, 石智 *

暨南大学生命科学技术学院 广东广州

*通讯作者: 石智,单位:暨南大学生命科学技术学院 广东广州;

发布时间: 2024-07-16 总浏览量: 152

摘要

生物技术的研究与发展在科技领域中逐渐占据了举足轻重的地位。因此,本文将回顾生物技术的主要发展历程,并分析在当今其发挥的作用以及应用前景,发现国内外在生物技术领域已经取得了显著进展,它的每一个分支都在为人类的进步做出巨大贡献。特别是对于医学领域的快速发展起积极的推动作用,我们将对基因检测、药物研发以及基因治疗这三个方面的发展与应用展开叙述。它们作为现代生物技术的重要组成部分,在当今已经取得许多新的突破,未来仍具有巨大发展空间。可以说生物技术在医学领域的应用取得了显著的进展,这为疾病诊断、预防、药物开发以及疾病治疗提供了新的手段和方法。随着技术的不断进步和创新,相信生物技术将在医学领域发挥更加重要的作用,为人类健康事业的发展做出更大的贡献。

关键词: 生物技术;医学;基因检测;药物研发;基因治疗

Abstract

The research and development of biotechnology has gradually occupied an important position in the field of science and technology. Therefore, this paper will review the main development history of biotechnology, analyze its role and application prospects in the present day, and discovered that significant progress has been made in the field of biotechnology at home and abroad, and every branch of it is making great contributions to the progress of human beings. In particular, it plays a positive role in promoting the rapid development of the medical field. We will describe the development and application of gene detection, drug research and development, and gene therapy. As an important part of modern biotechnology, they have made many new breakthroughs today and still have huge room for development in the future. It can be said that the application of biotechnology in the medical field has made remarkable progress, which provides new means and methods for disease diagnosis, prevention, drug development and disease treatment. With the continuous advancement and innovation of technology, it is believed that biotechnology will play a more important role in the medical field and make greater contributions to the development of human health.

Key words: Biotechnology; Medicine; Gene detection; Drug research and development; Gene therapy

参考文献 References

[1] Woollett, G.R. Innovation in biotechnology: current and future states. Clinical Pharmacology & Therapeutics, 2012, 91(1): p. 17-20. 

[2] 吴函蓉, 王莹, 杨力, 等. 我国生物技术基地平台现状与发展建议. 中国生物工程杂志, 2021, 41(11): p. 119-123.

[3] Mohammadi, G.A. Investigating the applications of biotechnology in food and agriculture. Plant Ecophysiology, 2024, 3(1): p. 40-47.

[4] 陈大明, 王莹, 濮润, 等. 生物技术时代: 新规律、新发展和新路径. 生命科学, 2018, 30(8): p. 891-895.

[5] Ganchozo, B.S.I., Indacochea, B.V.A., Villacreses, J.C.P., et al. Promising applications of biotechnology: boosting health, agriculture and environmental sustainability. Migration Letters, 2024, 21(S1): p. 794-800.

[6] 王大维. 现代生物技术的研究概况. 兽医卫生, 2022, 38(7): p. 90-91.

[7] 王丽潍. 食品检测中生物检测技术的应用. 食品安全导刊, 2023, 35(1): p. 178-180.

[8] Khoshandam, M., Soltaninejadoo, H., Mousazadeh, M., et al. Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine. Genes & Diseases, 2023, 11(1): p. 268-282.

[9] Zand, M., Narasu, M.L. A review article biotechnology applications in medicine. International Research Journal of Basic and Applied Science, 2019, 4(9): p. 2557-2563.

[10] Stevanovski, I., Chintalaphani, S.R., Gamaarachchi, H., et al. Comprehensive genetic diagnosis of tandem repeat expansion disorders with programmable targeted nanopore sequencing. Science Advances, 2022, 8(9): eabm5386. 

[11] Rajan-Babu, I.S., Dolzhenko, E., Eberle, M.A., et al. Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications. Nature Reviews Genetics, 2024, 10.

[12] 中华预防医学会出生缺陷与控制专业委员会新生儿遗传代谢病筛查学组, 中华医学会儿科学分会新生儿学组. 中国新生儿基因筛查专家共识:高通量测序在单基因病筛查中的应用. 中华实用儿科临床杂志, 2023, 38(1) : p. 31-36.

[13] Zheng, R.S., Chen, R., Han, B.F., et al. Cancer incidence and mortality in China, 2022. Zhonghua Zhong Liu Za Zhi, 2024, 46(3): p. 221-231.

[14] Wang, D.F., Liu, B.L., and Zhang, Z.M. Accelerating the understanding of cancer biology through the lens of genomics. Cell, 2023, 186(8): p. 1755-1771. 

[15] Shen, X.H., Dai, J., Guo, L.C., et al. Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis. NPJ Precision Oncology, 2024, 8(1): 30. 

[16] 杨燕, 高勇, 杨鹏, 等. 大数据时代下生物信息技术在生物医药领域的应用及发展. 数据, 2023, 1(1): p. 31-32.

[17] Keerthana, P., and Gochhait, S. Application of bioinformatics in health care and medicine. Information Retrieval in Bioinformatics, 2022: p. 83-99.

[18] Williams, C.L.H., Shepard, M., Slamon, D.J., and Ullrich, A honored with the 2019 Lasker-DeBakey Clinical Medical Research Award. Journal of Clinical Investigation, 2019, 129(10): p. 3963-3965.

[19] Dolgin, E. The tangled history of mRNA vaccines. Nature, 2021, 597(7876): p. 318-324. 

[20] 肖子怡, 吴晓敏, 关凡, 等. mRNA疫苗: 战胜新型冠状病毒感染的重要突破, 生物化学与生物物理进展. 2023, 50(12): p. 2770-2790.

[21] Beksultanova, A., Valeev, S., and Amirova, E. European hydrogen market and its potential for Russian business. E3S Web of Conferences: VI International Conference on Actual Problems of the Energy Complex and Environmental Protection (APEC-VI-2023), 2023, 411: 01012.

[22] Ghewari, P.G., Ghatage, A.A., and Sonavale, R.M. Medical biotechnology in combatting rare genetic disorders: A review of recent advances. Naturalista Campano, 2024, 28(1): p. 69-76. 

[23] 史彤, 李积宗. 基因治疗发展现状及展望. 药学实践与服务, 2022, 40(4): p. 296-301. 

[24] 任云晓, 肖茹丹, 娄晓敏, 等. 基因编辑技术及其在基因治疗中的应用. 遗传. 2019, 41(1): 18-27.

[25] Sharma, S., Boelens, J.J., Cancio, M., et al. CRISPR-Cas9 editing of the HBG1 and HBG2 promoters to treat sickle cell disease. The New England Journal of Medicine, 2023, 389(9): p. 820-832. 

[26] Newby, G.A., Yen, J.S., Woodard, K.J., et al. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature, 2021, 595(7866): p. 295-302. 

[27] Fu, B., Liao, J.Y., Chen, S.H., et al. CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia. Nature Medicine, 2022, 28(8): p. 1573-1580.

[28] Mohammadi, M.A., Maximiano, M.R., Hosseini, S.M., et al. CRISPR-Cas engineering in food science and sustainable agriculture: recent advancements and applications. Bioprocess and Biosystems Engineering, 2023, 46(4): p. 483-497. 

[29] Pacesa, M., Pelea, O., and Jinek, M. Past, present, and future of CRISPR genome editing technologies. Cell, 2024, 187(5): p. 1076-1100.

引用本文

苏玉斌, 石智, 生物技术在医学中的研究进展[J]. 现代生物技术研究, 2024; 2: (1) : 43-47.